Original Full Length ArticleHypophosphatemic rickets is associated with disruption of mineral orientation at the nanoscale in the flat scapula bones of rachitic mice with development☆,☆☆
Highlights
► During murine scapulae development, mineral nanoplatelet alignment and content increase faster in the periphery compared to the intermediate region. ► In the rachitic condition, nanoscale mineral orientation and direction are altered together with altered muscle forces and reduced mineralisation. ► Nanostructural mineral parameters may mediate fracture and deformability in rickets via association between muscle forces and mineral alignment.
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Funding sources: Medical Research Council UK; Diamond Light Source Ltd., Diamond House, Oxfordshire, UK; School of Engineering and Material Sciences, Queen Mary University of London, London, E1 4NS, UK; Engineering and Physical Research Council (EPSRC) UK, Swindon, UK.
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Conflict of interest: all authors have no conflict of interest.