Alcohol intake and bone status in elderly Japanese men: Baseline data from the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study

Kouda, Katsuyasu; Iki, Masayuki; Fujita, Yuki; Tamaki, Junko; Yura, Akiko; Kadowaki, Eiko; Sato, Yuho; Moon, Jong-Seong; Morikawa, Masayuki; Tomioka, Kimiko; Okamoto, Nozomi; Kurumatani, Norio

doi:10.1016/j.bone.2011.04.010

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Volume 49, Issue 2 , Pages 275-280, August 2011

Alcohol intake and bone status in elderly Japanese men: Baseline data from the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study

Katsuyasu Kouda
- Department of Public Health, Kinki University Faculty of Medicine, 377-2 Oono-higashi, Osaka-Sayama, Osaka 589-8511, Japan
Masayuki Iki
- Department of Public Health, Kinki University Faculty of Medicine, 377-2 Oono-higashi, Osaka-Sayama, Osaka 589-8511, Japan
- Corresponding author. Fax: +81 72 367 8262.
Yuki Fujita
- Department of Public Health, Kinki University Faculty of Medicine, 377-2 Oono-higashi, Osaka-Sayama, Osaka 589-8511, Japan
Junko Tamaki
- Department of Public Health, Kinki University Faculty of Medicine, 377-2 Oono-higashi, Osaka-Sayama, Osaka 589-8511, Japan
Akiko Yura
- Department of Public Health, Kinki University Faculty of Medicine, 377-2 Oono-higashi, Osaka-Sayama, Osaka 589-8511, Japan
Eiko Kadowaki
- Department of Public Health, Kinki University Faculty of Medicine, 377-2 Oono-higashi, Osaka-Sayama, Osaka 589-8511, Japan
Yuho Sato
- Department of Human Life, Jin-ai University, 3-1-1 Ote, Echizen, Fukui 915-8586, Japan
Jong-Seong Moon
- Faculty of Human Sciences, Taisei-gakuin University, 1060-1 Hirao, Mihara-ku, Sakai, Osaka 587-8555, Japan
Masayuki Morikawa
- Sakai City Mental Health Center, 5-1-4 Shinkanaoka, Kita-ku, Sakai, Osaka 591-8021, Japan
Kimiko Tomioka
- Department of Community Health and Epidemiology, Nara Medical University School of Medicine, 840 Shijocho, Kashihara, Nara 634-8521, Japan
Nozomi Okamoto
- Department of Community Health and Epidemiology, Nara Medical University School of Medicine, 840 Shijocho, Kashihara, Nara 634-8521, Japan
Norio Kurumatani
- Department of Community Health and Epidemiology, Nara Medical University School of Medicine, 840 Shijocho, Kashihara, Nara 634-8521, Japan

Received 27 December 2010; received in revised form 4 March 2011; accepted 13 April 2011. published online 10 May 2011.

Edited by: Toshio Matsumoto

Abstract

There are no data concerning a relationship between alcohol and bone status from a large-scale community-based study of elderly Japanese men. The baseline survey for the Fujiwara-kyo Osteoporosis Risk in Men Study was performed in 2174 male participants during the period from 2007 to 2008 in Nara Prefecture, Japan. Among them 1665 fitted the following inclusion criteria: (a) age ≥65years, (b) no diseases or drug therapy that could affect bone mineral density (BMD). We analyzed 1421 men with complete information about alcohol intake. We found that alcohol intake and BMD were positively correlated after adjustment for age, body mass index, natto intake, milk intake, smoking, physical activity, education, marital status, and hypertension. Adjusted total hip BMD of men with alcohol intake >39g/day was 0.90g/cm² and that of abstainers was 0.85g/cm². With regard to bone turnover markers, alcohol intake was inversely associated with serum levels of osteocalcin and tartrate-resistant acid phosphatase isoenzyme 5b. A two-piece linear regression model revealed a positive relationship between alcohol intake and crude mean BMD for the total hip in those with alcohol intake of less than 55g/day. In contrast, alcohol intake and BMD in those with an alcohol intake of 55g/day or more was inversely correlated. The present large-scale study of elderly Japanese men revealed that although an alcohol intake of <55g/day was positively correlated to BMD, alcohol intake of ≥55g/day was inversely correlated to BMD.

Research highlights

► Little is known about a relationship of alcohol with bone in elderly Japanese men. ► The FORMEN Study is a large-scale community-based study in Japan. ► Moderate alcohol intake was related to high bone mineral density in the FORMEN Study.

Abbreviations: BMD, bone mineral density, BMI, body mass index, CI, confidence interval, CV, coefficient of variation, DXA, dual X-ray absorptiometry, FORMEN, Fujiwara-kyo Osteoporosis Risk in Men, METs, metabolic equivalents, OC, osteocalcin, OR, odds ratio, Q, quartiles, SD, standard deviation, TRACP5b, tartrate-resistant acid phosphatase isoenzyme 5b