Bone
Volume 39, Issue 4 , Pages 678-683, October 2006

Mesenchymal stem cells for bone, cartilage, tendon and skeletal muscle repair

  • Mauro Krampera

      Affiliations

    • Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Italy
    • Corresponding Author InformationCorresponding author. Sezione di Ematologia, Policlinico ‘G.B. Rossi’, P.le L.A. Scuro 10, 37134 Verona, Italy. Fax: +39 045 50 18 07.
    • ,
  • Giovanni Pizzolo

      Affiliations

    • Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Italy
    • ,
  • Giuseppe Aprili

      Affiliations

    • Immunohematology and Transfusional Service-Tissue Bank, Azienda Ospedaliera of Verona, Italy
    • ,
  • Massimo Franchini

      Affiliations

    • Immunohematology and Transfusional Service-Tissue Bank, Azienda Ospedaliera of Verona, Italy

Received 24 February 2006; received in revised form 13 April 2006; accepted 14 April 2006. published online 09 June 2006.

Abstract 

Literature data concerning the biology and differentiation potential of mesenchymal stem cells (MSCs) have become huge in less than 10 years, although some of these data still remain contradictory. MSCs seem to be a very promising tool for cell therapy because of their peculiar characteristics, which mimic partially those of embryonic stem cells, but with some advantages in terms of availability, expandability, transplantability, and ethical implications. We discuss here the potential use of MSCs in degenerative or inflammatory diseases involving bone, cartilage, tendon and muscle tissues, on the basis of the experimental evidence.

Keywords: Mesenchymal stem cells, Regenerative medicine, Tissue repair

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PII: S8756-3282(06)00438-8

doi:10.1016/j.bone.2006.04.020

Bone
Volume 39, Issue 4 , Pages 678-683, October 2006

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