Bone
Volume 35, Issue 4 , Pages 842-849 , October 2004

Adiponectin and its receptors are expressed in bone-forming cells

  • Heidi S. Berner

      Affiliations

    • Corresponding Author InformationCorresponding author. Oral Research Laboratory, Institute for Clinical Dentistry, University of Oslo, PO Box 1109 Blindern, Oslo N-0317, Norway. Fax: +47-22-85-23-51.
    • Oral Research Laboratory, Institute for Clinical Dentistry, University of Oslo, Norway
    • ,
  • Staale P. Lyngstadaas

      Affiliations

    • Oral Research Laboratory, Institute for Clinical Dentistry, University of Oslo, Norway
    • ,
  • Axel Spahr

      Affiliations

    • Department of Conservative Dentistry and Periodontology, University of Ulm, Germany
    • ,
  • Marta Monjo

      Affiliations

    • Oral Research Laboratory, Institute for Clinical Dentistry, University of Oslo, Norway
    • ,
  • Liv Thommesen

      Affiliations

    • Department of Cancer Research and Molecular Medicine, University of Science and Technology, Trondheim, Norway
    • ,
  • Christian A. Drevon

      Affiliations

    • Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway
    • ,
  • Unni Syversen

      Affiliations

    • Department of Cancer Research and Molecular Medicine, University of Science and Technology, Trondheim, Norway
    • ,
  • Janne E. Reseland

      Affiliations

    • Oral Research Laboratory, Institute for Clinical Dentistry, University of Oslo, Norway

Received 22 March 2004 ,Revised 11 June 2004 ,Accepted 14 June 2004.

References 

  1. Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem. 1996;271:10697–10703
  2. Nakano Y, Tobe T, Choi-Miura NH, Mazda T, Tomita M. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J. Biochem. (Tokyo). 1996;120:803–812
  3. Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem. Biophys. Res. Commun. 1996;221:286–289
  4. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem. 1995;270:26746–26749
  5. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, et al.  Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 1999;257:79–83
  6. Combs TP, Berg AH, Obici S, Scherer PE, Rossetti L. Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J. Clin. Invest. 2001;108:1875–1881
  7. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat. Med. 2001;7:947–953
  8. Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Erickson MR, Yen FT, et al.  Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc. Natl. Acad. Sci. U. S. A. 2001;98:2005–2010
  9. Ouchi N, Kihara S, Arita Y, Maeda K, Kuriyama H, Okamoto Y, et al.  Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation. 1999;100:2473–2476
  10. Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S, Ouchi N, et al.  Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler. Thromb. Vasc. Biol. 2003;23:85–89
  11. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, et al.  Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler. Thromb. Vasc. Biol. 2000;20:1595–1599
  12. Kishida K, Nagaretani H, Kondo H, Kobayashi H, Tanaka S, Maeda N, et al.  Disturbed secretion of mutant adiponectin associated with the metabolic syndrome. Biochem. Biophys. Res. Commun. 2003;306:286–292
  13. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, et al.  Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003;423:762–769
  14. Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R. Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 2002;290:1084–1089
  15. Kharroubi I, Rasschaert J, Eizirik DL, Cnop M. Expression of adiponectin receptors in pancreatic beta cells. Biochem. Biophys. Res. Commun. 2003;312:1118–1122
  16. Tomas E, Tsao TS, Saha AK, Murrey HE, Zhang Cc, Itani SI, et al.  Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc. Natl. Acad. Sci. U. S. A. 2002;99:16309–16313
  17. Reseland JE, Syversen U, Bakke I, Qvigstad G, Eide LG, Hjertner O, et al.  Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization. J. Bone Miner. Res. 2001;16:1426–1433
  18. Reseland JE, Gordeladze JO. Role of leptin in bone growth: central player or peripheral supporter?. FEBS Lett. 2002;528:40–42
  19. Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, et al.  Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell. 2000;100:197–207
  20. Stein GS, Lian JB, Stein JL, Van Wijnen AJ, Montecino M. Transcriptional control of osteoblast growth and differentiation. Physiol. Rev. 1996;76:593–629
  21. Dennis JE, Charbord P. Origin and differentiation of human and murine stroma. Stem Cells. 2002;20:205–214
  22. Lenchik L, Register TC, Hsu FC, Lohman K, Nicklas BJ, Freedman BI, et al.  Adiponectin as a novel determinant of bone mineral density and visceral fat. Bone. 2003;33:646–651
  23. Fodstad O, Brogger A, Bruland O, Solheim OP, Nesland JM, Pihl A. Characteristics of a cell line established from a patient with multiple osteosarcoma, appearing 13 years after treatment for bilateral retinoblastoma. Int. J. Cancer. 1986;38:33–40
  24. Larsen RH, Bruland OS, Hoff P, Alstad J, Lindmo T, Rofstad EK. Inactivation of human osteosarcoma cells in vitro by 211At-TP-3 monoclonal antibody: comparison with astatine-211-labeled bovine serum albumin, free astatine-211 and external-beam X rays. Radiat. Res. 1994;139:178–184
  25. Wabitsch M, Brenner RE, Melzner I, Braun M, Moller P, Heinze E, et al.  Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation. Int. J. Obes. Relat. Metab. Disord. 2001;25:8–15
  26. Kappes A, Loffler G. Influences of ionomycin, dibutyryl-cycloAMP and tumour necrosis factor-alpha on intracellular amount and secretion of apM1 in differentiating primary human preadipocytes. Horm. Metab. Res. 2000;32:548–554
  27. Yokota T, Meka CS, Kouro T, Medina KL, Igarashi H, Takahashi M, et al.  Adiponectin, a fat cell product, influences the earliest lymphocyte precursors in bone marrow cultures by activation of the cyclooxygenase-prostaglandin pathway in stromal cells. J. Immunol. 2003;171:5091–5099
  28. Compston JE. Bone marrow and bone: a functional unit. J. Endocrinol. 2002;173:387–394
  29. Bernstein EL, Koutkia P, Ljungquist K, Breu J, Canavan B, Grinspoon S. Acute regulation of adiponectin by free fatty acids. Metabolism. 2004;53:790–793
  30. Fasshauer M, Kralisch S, Klier M, Lossner U, Bluher M, Klein J, et al.  Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 2003;301:1045–1050
  31. Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R. Adiponectin gene expression is inhibited by beta-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes. FEBS Lett. 2001;507:142–146
  32. Halleux CM, Takahashi M, Delporte ML, Detry R, Funahashi T, Matsuzawa Y, et al.  Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue. Biochem. Biophys. Res. Commun. 2001;288:1102–1107
  33. Combs TP, Wagner JA, Berger J, Doebber T, Wang WJ, Zhang BB, et al.  Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology. 2002;143:998–1007
  34. Hihi AK, Michalik L, Wahli W. PPARs: transcriptional effectors of fatty acids and their derivatives. Cell. Mol. Life Sci. 2002;59:790–798
  35. Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T, et al.  Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J. Biol. Chem. 2004;279:1304–1309
  36. Brakenhielm E, Veitonmaki N, Cao R, Kihara S, Matsuzawa Y, Zhivotovsky B, et al.  Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc. Natl. Acad. Sci. U. S. A. 2004;101:2476–2481
  37. Yokota T, Meka CS, Medina KL, Igarashi H, Comp PC, Takahashi M, et al.  Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins. J. Clin. Invest. 2002;109:1303–1310
  38. Yokota T, Oritani K, Takahashi I, Ishikawa J, Matsuyama A, Ouchi N, et al.  Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood. 2000;96:1723–1732
  39. Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, et al.  Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation. 2000;102:1296–1301
  40. Tsao TS, Murrey HE, Hug C, Lee DH, Lodish HF. Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30). J. Biol. Chem. 2002;277:29359–29362

PII: S8756-3282(04)00259-5

doi: 10.1016/j.bone.2004.06.008

Bone
Volume 35, Issue 4 , Pages 842-849 , October 2004

Article Tools

* Image Usage & Resolution