Bone
Volume 33, Issue 4 , Pages 475-484 , October 2003

Uniaxial cyclic stretch induces osteogenic differentiation and synthesis of bone morphogenetic proteins of spinal ligament cells derived from patients with ossification of the posterior longitudinal ligaments

  • M Tanno

      Affiliations

    • Department of Orthopaedic Surgery, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan
    • ,
  • K.-I Furukawa

      Affiliations

    • Department of Pharmacology, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan
    • Corresponding Author InformationCorresponding author. Department of Pharmacology, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan. Fax: +81-172-39-5023.
    • ,
  • K Ueyama

      Affiliations

    • Department of Orthopaedic Surgery, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan
    • ,
  • S Harata

      Affiliations

    • Department of Orthopaedic Surgery, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan
    • ,
  • S Motomura

      Affiliations

    • Department of Pharmacology, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan

Received 17 February 2003 ,Revised 18 May 2003 ,Accepted 21 May 2003.

References 

  1. Resnick D, Shaul SR, Robins JM. Diffuse idiopathic skeletal hyperostosis (DISH) (Forestier's disease with extraspinal manifestations). Radiology. 1975;115:513–524
  2. Forestier J, Lagier R. Ankylosing hyperostosis of the spine. Clin Orthop. 1971;74:65–83
  3. Tanno T. Experimental study on the spinal lesions in hyperostotic mouse (twy/twy) (special reference to the pathogenesis of the ossification of the spinal osteoblast differentiation of the spinal ligaments and to the action of ethane-1-hydroxy-1, 1-diphosphonate). Nippon Seikeigeka Gakkai Zasshi. 1992;66:1073–1083
  4. Okawa A, Goto S, Moriya H. Calcitonin simultaneously regulates both periosteal hyperostosis and trabecular osteopenia in the spinal hyperostotic mouse (twy/twy) in vivo. Calcif Tissue Int. 1999;64:239–247
  5. Hashizume Y. Pathological studies on the ossification of the posterior longitudinal ligament (opll). Acta Pathol Jpn. 1980;30:255–273
  6. Yamamoto Y, Furukawa K-I, Ueyama K, Nakanishi T, Takigawa M, Harata S. Possible roles of CTGF/Hcs24 in the initiation and development of ossification of the posterior longitudinal ligament. Spine. 2002;27:1852–1857
  7. Koga H, Sakou T, Taketomi E, Hayashi K, Numasawa T, Harata S, et al. Genetic mapping of ossification of the posterior longitudinal ligament of the spine. Am J Hum Genet. 1998;62:1460–1467
  8. Numasawa T, Koga H, Ueyama K, Maeda S, Sakou T, Harata S, et al. Human retinoic X receptor beta (complete genomic sequence and mutation search for ossification of posterior longitudinal ligament of the spine). J Bone Miner Res. 1999;14:500–508
  9. Wang PN, Chen SS, Liu HC, Fuh JL, Kuo BI, Wang SJ. Ossification of the posterior longitudinal ligament of the spine (a case-control risk factor study). Spine. 1999;24:142–144
  10. Baba H, Furusawa N, Fukuda M, Maezawa Y, Imura S, Kawahara N, et al. Potential role of streptozotocin in enhancing ossification of the posterior longitudinal ligament of the cervical spine in the hereditary spinal hyperostotic mouse (twy/twy). Eur J Histochem. 1997;41:191–202
  11. Goto K, Yamazaki M, Tagawa M, Goto S, Kon T, Moriya H, et al. Involvement of insulin-like growth factor I in development of ossification of the posterior longitudinal ligament of the spine. Calcif Tissue Int. 1998;62:158–165
  12. Inaba K, Matsunaga S, Ishidou Y, Imamura T, Yoshida H. Effect of transforming growth factor-beta on fibroblasts in ossification of the posterior longitudinal ligament. In Vivo. 1996;10:445–449
  13. Ishida Y, Kawai S. Characterization of cultured cells derived from ossification of the posterior longitudinal ligament of the spine. Bone. 1993;14:85–91
  14. Ishida Y, Kawai S. Effects of bone-seeking hormones on DNA synthesis, cyclic AMP level, and alkaline phosphatase activity in cultured cells from human posterior longitudinal ligament of the spine. J Bone Miner Res. 1993;8:1291–1300
  15. Kon T, Yamazaki M, Tagawa M, Goto S, Terakado A, Moriya H, et al. Bone morphogenetic protein-2 stimulates differentiation of cultured spinal ligament cells from patients with ossification of the posterior longitudinal ligament. Calcif Tissue Int. 1997;60:291–296
  16. Yonemori K, Imamura T, Ishidou Y, Okano T, Matsunaga S, Yoshida H, et al. Bone morphogenetic protein receptors and activin receptors are highly expressed in ossified ligament tissues of patients with ossification of the posterior longitudinal ligament. Am J Pathol. 1997;150:1335–1347
  17. Matsunaga S, Sakou T, Taketomi E, Yamaguchi M, Okano T. The natural course of myelopathy caused by ossification of the posterior longitudinal ligament in the cervical spine. Clin Orthop. 1994;305:168–177
  18. Nakamura H. A radiographic study of the progression of ossification of the cervical posterior longitudinal ligament (the correlation between the ossification of the posterior longitudinal ligament and that of the anterior longitudinal ligament). Nippon Seikeigeka Gakkai Zasshi. 1994;68:725–736
  19. Takatsu T, Ishida Y, Suzuki K, Inoue H. Radiological study of cervical ossification of the posterior longitudinal ligament. J Spinal Disord. 1999;12:271–273
  20. White AA, Panjabi MM. Clinical biomechanics of the spine. 2nd ed.. Philadelphia: Lippincott-Raven; 1990;
  21. Matusnaga S, Sakou T, Taketomi E, Nakanishi K. Effects of strain distribution in the intervertebral discs on the progression of ossification of the posterior longitudinal ligaments. Spine. 1996;21:184–189
  22. Robinson JA, Harris SA, Riggs BL, Spelsberg TC. Estrogen regulation of human osteoblastic cell proliferation and differentiation. Endocrinology. 1997;138:2919–2927
  23. Chicurel ME, Singer RH, Meyer CJ, Ingber DE. Integrin binding and mechanical tension induce movement of mRNA and ribosomes to focal adhesions. Nature. 1998;392:730–733
  24. Chiquet M, Matthisson M, Koch M, Tannheimer M, Chiquet-Ehrismann R. Regulation of extracellular matrix synthesis by mechanical stress. Biochem Cell Biol. 1996;74:737–744
  25. Akhouayri O, Lafage-Proust MH, Rattner A, Laroche N, Caillot-Augusseau A, Alexandre C, et al. Effects of static or dynamic mechanical stresses on osteoblast phenotype expression in three-dimensional contractile collagen gels. J Cell Biochem. 1999;76:217–230
  26. Dodds RA, Ali N, Pead MJ, Lanyon LE. Early loading-related changes in the activity of glucose 6-phosphate dehydrogenase and alkaline phosphatase in osteocytes and periosteal osteoblasts in rat fibulae in vivo. J Bone Miner Res. 1993;8:261–267
  27. Pavlin D, Dove SB, Zadro R, Gluhak-Heinrich J. Mechanical loading stimulates differentiation of periodontal osteoblasts in a mouse osteoinduction model (effect on type I collagen and alkaline phosphatase genes). Calcif Tissue Int. 2000;67:163–172
  28. Cillo JE, Gassner R, Koepsel RR, Buckley MJ. Growth factor and cytokine gene expression in mechanically strained human osteoblast-like cells (implications for distraction osteogenesis). Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90:147–154
  29. Duncan RL, Hruska KA. Chronic, intermittent loading alters mechanosensitive channel characteristics in osteoblast-like cells. Am J Physiol. 1994;267:F909–F916
  30. Lee J, Ishihara A, Oxford G, Johnson B, Jacobson K. Regulation of cell movement is mediated by stretch-activated calcium channels. Nature. 1999;400:382–386
  31. Biagi BA, Enyeart JJ. Gadolinium blocks low- and high-threshold calcium currents in pituitary cells. Am J Physiol. 1990;259:C515–520
  32. Miyauchi A, Notoya K, Mikuni-Takagaki Y, Takagi Y, Goto M, Miki Y, et al. Parathyroid hormone-activated volume-sensitive calcium influx pathways in mechanically loaded osteocytes. J Biol Chem. 2000;275:3335–3342
  33. Zimmermann B, Lange K, Mertens P, Bernimooulin JP. Inhibition of chondrogenesis and endochondral mineralization in vitro by different calcium channel blockers. Eur J Cell Biol. 1994;63:14–121
  34. Urist MR. Bone (formation by autoinduction). Science. 1965;150:893–899
  35. Rosen V, Cox K, Hattersley G. Bone morphogenetic proteins. In:  Bilezikian JP,  Raisz LG,  Rodan GA editor. Principles of bone biology. Cambridge, MA, USA: Academic Press; 1996;p. 661–671
  36. Kawasaki K, Aihara M, Honmo J, Sakurai S, Fujimaki Y, Sakamoto K, et al. Effects of recombinant human bone morphogenetic protein-2 on differentiation of cells isolated from human bone, muscle, and skin. Bone. 1998;23:223–231
  37. Harris SE, Bonewald LF, Harris MA, Sabatini M, Dallas S, Feng JQ, et al. Effects of transforming growth factor beta on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts. J Bone Miner Res. 1994;9:855–863
  38. Yamaguchi A, Ishizuya T, Kintou N, Wada Y, Katagiri T, Wozney JM, et al. Effects of BMP-2, BMP-4, and BMP-6 on osteoblastic differentiation of bone marrow derived stromal cell lines, ST2 and MC3T3-G2/PA6. Biochem Biophys Res Commun. 1996;220:366–371
  39. Reddi AH. Roll of morphogenetic proteins in skeletal tissue engineering and regeneration. Nature Biotechnol. 1998;16:247–252
  40. Ishidou Y, Kitajima I, Obama H, Maruyama I, Murata F, Imamura T, et al. Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation. J. Bone Miner Res. 1995;10:1651–1659
  41. Chen D, Ji X, Harris MA, Feng JQ, Karsenty G, Celeste AJ, et al. Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages. J Cell Biol. 1998;142:295–305
  42. Feng JQ, Harris MA, Ghosh-Choundhury N, Feng M, Mundy GR, Harris SE. Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2) (comparison of the structures and promoter regions of BMP-2 and BMP-4 genes). Biochim Biophys Acta. 1994;1218:221–224
  43. Feng JQ, Chen D, Cooney AJ, Tsai MJ, Harris MA, Tsai SY, et al. The mouse bone morphogenetic protein-4 gene (analysis of promoter utilization in fetal rat calvarial osteoblast and regulation by COUP-TFI orphan receptor). J Biol Chem. 1995;270:28364–28373
  44. Naruse K, Yamada T, Sokabe M. Involvement of SA channels in orienting response of cultured endotherial cells to cyclic stretch. Am J Physiol. 1988;274:H1532–1538
  45. Laemmli UK. Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature. 1970;227:680–685

PII: S8756-3282(03)00204-7

doi: 10.1016/S8756-3282(03)00204-7

Bone
Volume 33, Issue 4 , Pages 475-484 , October 2003

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