-
Anatomical distribution of the degree of mineralization of bone tissue in human femoral neck: Impact on biomechanical properties
27 January 2012
V. Sansalone, V. Bousson, S. Naili, C. Bergot, F. Peyrin, J.D. Laredo, G. Haïat
Abstract: Osteoporotic hip fractures represent a major public health problem associated with high human and economic costs. The anatomical variation of the tissue mineral density (TMD) and of the elas...
-
Medication adherence and fracture risk among patients on bisphosphonate therapy in a large United States health plan
27 January 2012
Sally W. Wade, Jeffrey R. Curtis, Jingbo Yu, Jeffrey White, Bradley S. Stolshek, Claire Merinar, Akhila Balasubramanian, Joel D. Kallich, John L. Adams, Hema N. Viswanathan
Abstract: The association between bisphosphonate adherence in the first 12months after therapy initiation and subsequent fracture risk was examined. Patients were identified from a large, commercially...
-
Effects of neonatal castration and androgenization on sexual dimorphism in bone, leptin and corticosterone secretion
27 January 2012
Wagner Garcez de Mello, Samuel Rodrigues Lourenço de Morais, Rita Cássia Menegati Dornelles, Lucila Leico Kagohara Elias, José Antunes-Rodrigues, João Cesar Bedran de Castro
Abstract: This study investigated the role of neonatal sex steroids in rats on sexual dimorphism in bone, as well as on leptin and corticosterone concentrations throughout the lifespan. Castration of ...
-
The effect of high versus low loading on bone strength in middle life
27 January 2012
C. Milgrom, N. Constantini, Y. Milgrom, D. Lavi, Y. Appelbaum, V. Novack, A. Finestone
Abstract: While bone mass and geometry are largely genetically determined, mechanical loading is considered to be an important additional determinant. This study investigates to what extent very high ...
-
Effects of Src kinase inhibition by saracatinib (AZD0530) on bone turnover in advanced malignancy in a Phase I study
27 January 2012
Rosemary A. Hannon, Richard D. Finkelman, Glen Clack, Renee B. Iacona, Martin Rimmer, Fatma Gossiel, José Baselga, Richard Eastell
Abstract: Saracatinib (AZD0530) is an orally active once-daily Src kinase inhibitor which modulates key signaling pathways in cancer cells. In a Phase I study in patients with advanced solid malignanc...
View More Articles in Press...